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And CCL2).46,47 In addition, RAGE expressed in endothelial cells is an important mediator of plaque formation. In fact, RAGE has long been known to promote the expression of adhesion proteins such as VCAM-1 in endothelial cells.111 During atherosclerosis, RAGE increases HMGB1 expression and release,112,113 and in vitro treatment of endothelial cells (human umbilical vein endothelial cells) with ex
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